Water → Methyl 4'-[[4-bromo-2-butyl-5-formyl-1H-imidazol-1-yl]-methyl]-(1,1'-biphenyl)-2-carboxylate

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Reaction Steps

3.7 g of the product of Step B were introduced into 50 ml of dimethylformamide and 2.46 g of potassium bicarbonate were added with stirring. Then, the mixture stood for about 5 minutes and 5.86 g of methyl bromomethyl-(1,1'-biphenyl)-2-carboxylate (prepared according to EP 0,253,310) in 55 ml of dimethylformamide were added. The mixture stood for 3 days at ambient temperature and the reaction medium was hydrolyzed with 100 ml of water, then extracted with ethyl acetate. The extracts were washed with water saturated with sodium chloride, dried, filtered and evaporated. After chromatography, (eluant: ethyl acetate 5-methylene chloride 95), 6.36 g of the expected product were recovered.

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