HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylene Glycol → 2-(4-Chlorobenzyl)-1-[4-(4-fluorophenyl)butyl]perhydroazepine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylene Glycol | HCID 8172 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | 2-(4-Chlorobenzyl)-1-[3-(4-fluorobenzoyl)propyl]perhydroazepine | HCID 23342853 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 2-(4-Chlorobenzyl)-1-[4-(4-fluorophenyl)butyl]perhydroazepine | HCID 23342834 | 62.2% |
Reaction Steps
Heat 0.5 g of the title compound of Example 39 with 1 ml of hydrazine hydrate, 0.5 g of potassium hydroxide and 5 ml of triglycol for 2 hours at 165°. Cool the resulting reaction mixture to ambient temperature. Mix the cooled reaction mixture with water and diethyl ether. Dry the ether phase over sodium sulfate and then concentrate it to obtain 0.3 g of the title compound as a viscous oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04221788 |
| Source dataset | uspto-grants-1980_09 |
| ORD ID | ord-263ae71c66374e658004a1b702d7a9d6 |
| Source note | uspto-grants-1980_09 |