反应详情

To an ice-cold solution of 4.47 g of 2-(4-chlorobenzyl)cyclohexanone in 100g of polyphosphoric acid add 2.6 g of sodium azide while stirring. Stir the mixture for another 1.5 hours at 0° and for a further 8 hours at room temperature, pour it into ice water and then extract it with methylene chloride. After drying the organic phase over sodium sulfate distill off the solvent to obtain 2.85 g of the title compound as a light brown oil.

1. stirringStir the mixture for another 1.5 hours at 0°
2. extractionextract it with methylene chloride
3. dry with materialAfter drying the organic phase over sodium sulfate
4. distillationdistill off the solvent