HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 9-(2-Hydroxypropyl)adenine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 9-(2-Hydroxy-1-propyl)-6-chloropurine | HCID 12065182 | — |
| Solvent | Ammonium Chloride | HCID 25517 | — |
| Product | 9-(2-Hydroxypropyl)adenine | HCID 1942 | — |
Reaction Steps
9-(2-Hydroxy-1-propyl)-6-chloropurine (I, 9 g, 42.5 mmol) was dissolved in saturated methanolic ammonia and ammonium chloride (50 mg). The mixture was heated at 130° in a bomb for 6 hr. The resulting solution was evaporated to dryness and recrystallized from ethanol/acetone. Yield=6.68 g of a colorless crystalline product (81%) mp 193°-194° uv (H2O; pH 5.5) λmax 260 nm TLC in CHl3 :MeOH (5:1) Rf 0.44
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04221794 |
| Source dataset | uspto-grants-1980_09 |
| ORD ID | ord-2b1883eca83b4eb5adf9116c61d353e7 |
| Source note | uspto-grants-1980_09 |