1,3,4-Thiadiazol-2-amine → 5-(Imidazo-[2,1-b]-1,3,4-thiadiazol-6-yl)-3-nitropyrocatechol

Participants

Reaction Steps

A solution of 1.38 g of 2-bromo-3',4'-dihydroxy-5'-nitroacetophenone and 505.7 mg of 2-amino-1,3,4-thiadiazole in 25 ml of n-butanol is heated to boiling under reflux for 7 hours. The reaction mixture is then cooled to room temperature and the separated crystals are filtered under suction. There is obtained 5-(imidazo-[2,1-b]-1,3,4-thiadiazol-6-yl)-3-nitropyrocatechol of m.p. 278°-280° (from methanol).

Provenance & Evidence