HCID 12841761, compound → 3-beta-(4-Carbamoylmethoxyphenylacetamido)ethylamino-1-(2-cyanophenoxy)-2-propanol

HRID 27453Notes

Reaction equation

HRID 27453 reaction equation
[NH2:1][CH2:2][CH2:3][NH:4][CH2:5][CH:6]([OH:17])[CH2:7][O:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[C:15]#[N:16].[C:18]([CH2:21][O:22][C:23]1[CH:28]=[CH:27][C:26]([CH2:29][C:30](OCC)=[O:31])=[CH:25][CH:24]=1)(=[O:20])[NH2:19]>>[C:18]([CH2:21][O:22][C:23]1[CH:28]=[CH:27][C:26]([CH2:29][C:30]([NH:1][CH2:2][CH2:3][NH:4][CH2:5][CH:6]([OH:17])[CH2:7][O:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[C:15]#[N:16])=[O:31])=[CH:25][CH:24]=1)(=[O:20])[NH2:19]

Participants

3

Reactant 2

HCID 12841761HCID 12841761, compoundHCID 20499321HCID 20499321, compound

Product 1

HCID 543263233-beta-(4-Carbamoylmethoxyphenylacetamido)ethylamino-1-(2-cyanophenoxy)-2-propanol

Procedure

In a similar manner using 2.36 g. of 3-(β-aminoethylamino)-1-(2-cyanophenoxy)-2-propanol and 2.37 g. of ethyl 4-carbamoylmethoxyphenylacetate as starting materials there is obtained 3-β-(4-carbamoylmethoxyphenylacetamido)ethylamino-1-(2-cyanophenoxy)-2-propanol, isolated as its hydrogen oxalate, m.p. 123°-125° C. after crystallisation from ethyl acetate.

Sources & evidence

ORD record
ord-fa680b5a429d4befaa2bced4292d7734
Source dataset
uspto-grants-1980_09
Patent number
US04221807

Reaction notes

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