Ethylenediamine → 3-beta-Aminoethylamino-1-(benzodioxan-5-yloxy)-2-propanol

HRID 27454Notes

Reaction equation

HRID 27454 reaction equation
[O:1]1[C:6]2[CH:7]=[CH:8][CH:9]=[C:10]([O:11][CH2:12][CH:13]3[O:15][CH2:14]3)[C:5]=2[O:4][CH2:3][CH2:2]1.[CH2:16]([NH2:19])[CH2:17][NH2:18]>>[NH2:18][CH2:17][CH2:16][NH:19][CH2:14][CH:13]([OH:15])[CH2:12][O:11][C:10]1[C:5]2[O:4][CH2:3][CH2:2][O:1][C:6]=2[CH:7]=[CH:8][CH:9]=1

Participants

3

Reactant 2

HCID 3301EthylenediamineHCID 37114295-(Oxiran-2-ylmethoxy)-2,3-dihydro-1,4-benzodioxine

Product 1

HCID 130640833-beta-Aminoethylamino-1-(benzodioxan-5-yloxy)-2-propanol

Procedure

A mixture of 20.8 g. of 1-(benzodioxan-5-yloxy)-2,3-epoxypropane and 120 g. of ethylenediamine is heated at 90° C. for 18 hours and is then evaporated to dryness under reduced pressure. The residue is stirred with 100 ml. of water and the mixture is extracted four times with 100 ml. of chloroform each time. The combined chloroform extracts are dried and evaporated to dryness under reduced pressure and there is thus obtained as residue 3-β-aminoethylamino-1-(benzodioxan-5-yloxy)-2-propanol.

Workup

  1. additionA mixture of 20.8 g
  2. customis then evaporated to dryness under reduced pressure
  3. extractionof water and the mixture is extracted four times with 100 ml
  4. dry with materialThe combined chloroform extracts are dried
  5. customevaporated to dryness under reduced pressure and there

Sources & evidence

ORD record
ord-80f52a07cc094d3b9f598a2ad8eed76c
Source dataset
uspto-grants-1980_09
Patent number
US04221807

Reaction notes

Loading…