反应详情

A solution of 1-(4-methylphenyl)pyrrole-2-carbonitrile (4.9 g), N-bromosuccinimide (5.5 g) and perbenzoic acid (65 mg) in carbon tetrachloride was heated under reflux in light radiation for 2 hours. After removal of insoluble materials by filtration, the filtrate was concentrated to dryness. The residue was purified by column chromatography on silica gel to afford a colorless syrup (6.6 g, 93%).

1. temperatureunder reflux in light radiation for 2 hours
2. customAfter removal of insoluble materials
3. filtrationby filtration
4. concentrationthe filtrate was concentrated to dryness
5. customThe residue was purified by column chromatography on silica gel