HCID 20093009, compound → HCID 20093029, compound

Participants

Reaction Steps

To a solution of 2'-cyanomethoxy-4-methylbenzophenone (8.9 g) in methanol (750 ml) was added CH3ONa (2.0 g) and molecular sieves (3A, 5 g) and the mixture was heated under reflux for 30 hours. After removal of insoluble materials by filtration, the filtrate was concentrated to dryness. The residue was dissolved in ethyl acetate, followed by removal of insoluble materials by filtration and concentration of the filtrate. The residue was purified by column chromatography on silica gel to afford pale yellow powders (3.34 g, 40%).

Provenance & Evidence