HCID 178441472, compound → HCID 178441467, compound

HRID 274572Notes

Reaction equation

HRID 274572 reaction equation
[CH2:1]([C:5]1[N:9]([CH2:10][C:11]2[CH:16]=[CH:15][C:14]([C:17]3[C:18]4[CH:30]=[CH:29][CH:28]=[CH:27][C:19]=4[O:20][C:21]=3[C:22]3[NH:26][N:25]=[N:24][N:23]=3)=[CH:13][CH:12]=2)[C:8]2[C:31]([C:35]([O:37]C)=[O:36])=[CH:32][CH:33]=[CH:34][C:7]=2[N:6]=1)[CH2:2][CH2:3][CH3:4]>CO>[CH2:1]([C:5]1[N:9]([CH2:10][C:11]2[CH:12]=[CH:13][C:14]([C:17]3[C:18]4[CH:30]=[CH:29][CH:28]=[CH:27][C:19]=4[O:20][C:21]=3[C:22]3[NH:26][N:25]=[N:24][N:23]=3)=[CH:15][CH:16]=2)[C:8]2[C:31]([C:35]([OH:37])=[O:36])=[CH:32][CH:33]=[CH:34][C:7]=2[N:6]=1)[CH2:2][CH2:3][CH3:4]

Participants

3

Reactant 1

HCID 178441472HCID 178441472, compound

Product 1

HCID 178441467HCID 178441467, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of methyl 2-butyl-1-[[4-[2-(1H-tetrazol-5-yl)benzo[b]furan-3-yl]phenyl]methyl]benzimidazole-7-carboxylate (1.1 g) 1N aqueous NaOH (12 ml) in methanol (50 ml) was stirred at room temperature for 24 hours. After evaporation of methanol, the residue was neutralized with 1N aqueous hydrochloric acid to precipitate crystals. Recrystallization from DMF-methanol afforded colorless crystals (0.82 g, 77%), m.p. 194°-195° C.

Workup

  1. customAfter evaporation of methanol
  2. customto precipitate crystals
  3. customRecrystallization from DMF-methanol afforded colorless crystals (0.82 g, 77%), m.p. 194°-195° C.

Sources & evidence

ORD record
ord-c6b3b87dc84340349ca8b82145fc1bf5
Source dataset
uspto-grants-1995_02
Patent number
US05389641

Reaction notes

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