反应详情

A solution of methyl 2-butyl-1-[[4-[2-(1H-tetrazol-5-yl)benzo[b]furan-3-yl]phenyl]methyl]benzimidazole-7-carboxylate (1.1 g) 1N aqueous NaOH (12 ml) in methanol (50 ml) was stirred at room temperature for 24 hours. After evaporation of methanol, the residue was neutralized with 1N aqueous hydrochloric acid to precipitate crystals. Recrystallization from DMF-methanol afforded colorless crystals (0.82 g, 77%), m.p. 194°-195° C.

1. customAfter evaporation of methanol
2. customto precipitate crystals
3. customRecrystallization from DMF-methanol afforded colorless crystals (0.82 g, 77%), m.p. 194°-195° C.