Sodium Hydroxide → HCID 178441469, compound

Participants

Reaction Steps

To a solution of methyl 2-butyl-1-[p-[4-(1H-tetrazol-5-yl)pyrimidin-5-yl]benzyl]benzimidazole-7-carboxylate (0.1 g, 0.2 mmol) in methanol (5 ml) was added 1N aqueous NaOH (0.5 ml) and the mixture was heated under reflux for 6 hours. After concentration to dryness, the residue was dissolved in water and the solution was neutralized with 1N aqueous hydrochloric acid. The resulting precipitate was collected by filtration and washed with water. Recrystallization from aqueous methanol afforded yellow powders (80 mg, 82%), m.p. 209°-212° C.

Provenance & Evidence