反应详情

A mixed solution of 2-nitro-4-methylbenzonitrile (15.8 g) in a mixture of 65% sulfuric acid and acetic acid (150 ml) was heated under reflux for 17 hours. After concentration, the residue was poured into ice-water and extracted with ethyl acetate. The extract was washed with water, dried and concentrated to dryness. Recrystallization of crystals from ether-hexane afforded colorless crystals (16.5 g, 94%), m.p. 156°-157° C.

1. temperaturewas heated
2. temperatureunder reflux for 17 hours
3. concentrationAfter concentration
4. additionthe residue was poured into ice-water
5. extractionextracted with ethyl acetate
6. washThe extract was washed with water
7. customdried
8. concentrationconcentrated to dryness
9. customRecrystallization of crystals from ether-hexane afforded colorless crystals (16.5 g, 94%), m.p. 156°-157° C.