2-Methyl-2-butene → HCID 178441921, compound

Participants

Reaction Steps

A solution of sodium chlorite (80%;0.44 g) and sodium dihydrogen phosphate (0.44 g) in water (5 ml) was added to a mixture of the product of Example 27 (203 mg), 2-methyl-2-butene (2M,0.62 ml) and t-butanol (4 ml) in THF (10 ml) at room temperature. The mixture was stirred vigorously for 20 mins. The mixture was partitioned between ethyl acetate (3×15 ml) and water (15 ml). The combined organic extracts were dried. The solvent was evaporated to give a colourless foam (0.2 g) which was purified by column chromatography on silica gel eluting with System G (50:50:1) to give the title compound as a colourless solid (60 mg).

Provenance & Evidence