1-Phenylpiperazine → HCID 54383782, compound

Participants

Reaction Steps

In dichloromethane (15 ml) was dissolved (2R 3R)-3-chlorosulfonyl-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2-butyl acetate (0.5 g). To the solution was added, under ice-cooling, 1-phenylpiperazine (0 27 g) The reaction mixture was stirred for 10 minutes under ice-cooling, which was then concentrated. The concentrate was subjected to a silica gel chromatography (eluent: hexane/ethyl acetate=1/2→ethyl acetate) for purification to give, as the first eluate, 1-[3-(2,4-difluorophenyl)-4-(1H-1,2,4-triazol-1-yl)-2-buten-2-ylsulfonyl]-4-phenylpiperazine (isomer B, Compound 31, 0.05 g) as a pale brown solid substance and, as the second eluate, 1-[3-(2,4-difluorophenyl)-4-(1H-1,2,4-triazol-1-yl)-2-buten-2-ylsulfonyl]-4-phenylpiperazine (isomer A, Compound 30, 0.18 g) as a pale brown solid substance.

Provenance & Evidence