Dimethylamine → HCID 54488087, compound

Participants

Reaction Steps

In dichloromethane (15 ml) was dissolved (2R,3R)-3-chlorosulfonyl-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2-butyl acetate (3.0 g). To the solution was added, under ice-cooling, dimethylamine (0.6 g). The reaction mixture was stirred for 10 minutes under ice-cooling, which was then concentrated. The concentrate was subjected to a silica gel chromatography (eluent: hexane/ethyl acetate=1/2→ethyl acetate) for purification to give, as the first eluate, N,N-dimethyl-3-(2,4-difluorophenyl)-4-(1H-1,2,4-triazol-1-yl)-2-butene-2-sulfonamide (isomer B, Compound 35, 0.48 g) as a pale yellow oily substance, and, as the second eluate, N,N-dimethyl-3-(2,4-difluorophenyl)-4-(1H-1,2,4-triazol-1-yl)-2-butene-2-sufonamide (isomer A, Compound 34, 0.80 g) as a pale yellow oily substance.

Provenance & Evidence