5-(4'-(Bromomethyl)(1,1'-biphenyl)-2-yl)-1-trityl-1H-tetraazole → 2-butyl-1-[(2'-{N-triphenylmethyltetrazol-5-yl}{1,1'-biphenyl}-4-yl)methyl]-1H-thieno-[3,4-d]imidazole

HRID 274615Notes

Reaction equation

HRID 274615 reaction equation
C(O[C:6]([C:8]1[C:9]([C:14]2[CH:19]=[CH:18][C:17]([CH2:20][N:21]3[C:25]4=[CH:26][S:27][CH:28]=[C:24]4[N:23]=[C:22]3[CH2:29][CH2:30][CH2:31][CH3:32])=[CH:16][CH:15]=2)=[CH:10][CH:11]=[CH:12][CH:13]=1)=O)(C)(C)C.[C:33]1([C:39]([C:65]2[CH:70]=[CH:69][CH:68]=[CH:67][CH:66]=2)([C:59]2[CH:64]=[CH:63][CH:62]=[CH:61][CH:60]=2)[N:40]2C(C3C=CC=CC=3C3C=CC(CBr)=CC=3)=[N:43][N:42]=[N:41]2)[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1>>[CH2:29]([C:22]1[N:21]([CH2:20][C:17]2[CH:18]=[CH:19][C:14]([C:9]3[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=3[C:6]3[N:40]([C:39]([C:33]4[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=4)([C:65]4[CH:66]=[CH:67][CH:68]=[CH:69][CH:70]=4)[C:59]4[CH:60]=[CH:61][CH:62]=[CH:63][CH:64]=4)[N:41]=[N:42][N:43]=3)=[CH:15][CH:16]=2)[C:25]2=[CH:26][S:27][CH:28]=[C:24]2[N:23]=1)[CH2:30][CH2:31][CH3:32]

Participants

3

Reactant 2

HCID 100534615-(4'-(Bromomethyl)(1,1'-biphenyl)-2-yl)-1-trityl-1H-tetraazoleHCID 538482894'-[(2-butyl-1H-thieno[3,4-d]imidazol-1-yl)methyl][1,1'-biphenyl]-2-carboxylic acid t-butyl ester

Product 1

HCID 200934232-butyl-1-[(2'-{N-triphenylmethyltetrazol-5-yl}{1,1'-biphenyl}-4-yl)methyl]-1H-thieno-[3,4-d]imidazole

Procedure

This Step A compound can be prepared in a similar fashion to the preparation of 4'-[(2-butyl-1H-thieno[3,4-d]imidazol-1-yl)methyl][1,1'-biphenyl]-2-carboxylic acid t-butyl ester (Example 1, Step B) except that the alkylating agent used can be 2'-(N-triphenylmethyltetrazol-5-yl)biphen-4-yl methyl bromide in place of t-butyl-4'-bromomethylbiphenyl-2-carboxylate.

Sources & evidence

ORD record
ord-3d03b90163e04e9283b67b0df9fddf47
Source dataset
uspto-grants-1995_02
Patent number
US05389660

Reaction notes

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