Triethylamine → HCID 20093314, compound

Participants

Reaction Steps

To a solution of 7.27 g (28.1 mmol) 4-[3-(N-benzylaminopropylthio)pyridine and 4.70 ml (33.7 mmol) of triethylamine in 150 ml of methylene chloride, 4.76 ml (33.7 mmol) of trifluoroacetic anhydride was added under ice-cooling with stirring. The mixture was stirred at room temperature for 30 minutes. The reaction mixture was washed with a saturated aqueous solution of sodium bicarbonate and water and dried, and then the solvent was distilled off. The residue was purified by column chromatography (eluent: ethyl acetate/hexane=2:1 to 1:1) to obtain 6.04 g of 4-[3-(N-benzyl-N-fluoroacetylamino)-propylthio]pyridine (yield: 60.7% yellow oil).

Provenance & Evidence