Acetic Anhydride → 2-(4-Carboxybenzamido)-4-acetamidobenzoic acid

HRID 27471Notes

Reaction equation

HRID 27471 reaction equation
[C:1]([C:4]1[CH:22]=[CH:21][C:7]([C:8]([NH:10][C:11]2[CH:19]=[C:18]([NH2:20])[CH:17]=[CH:16][C:12]=2[C:13]([OH:15])=[O:14])=[O:9])=[CH:6][CH:5]=1)([OH:3])=[O:2].[C:23](OC(=O)C)(=[O:25])[CH3:24]>>[C:1]([C:4]1[CH:5]=[CH:6][C:7]([C:8]([NH:10][C:11]2[CH:19]=[C:18]([NH:20][C:23](=[O:25])[CH3:24])[CH:17]=[CH:16][C:12]=2[C:13]([OH:15])=[O:14])=[O:9])=[CH:21][CH:22]=1)([OH:3])=[O:2]

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 233430382-(4-Carboxybenzamido)-4-aminobenzoic acid

Product 1

HCID 233430402-(4-Carboxybenzamido)-4-acetamidobenzoic acidYield 63%

Procedure

The procedure of Example 4 was repeated to react 2-(4-carboxybenzamido)-4-aminobenzoic acid with acetic anhydride, and the reaction product was treated as in Example 4 to yield 63% of 2-(4-carboxybenzamido)-4-acetamidobenzoic acid having a melting point in the range of from 302° to 304° C. (decompose).

Workup

  1. additionthe reaction product was treated as in Example 4

Sources & evidence

ORD record
ord-c5a34530c1b6401a99fdc28327f2a46b
Source dataset
uspto-grants-1980_09
Patent number
US04221814

Reaction notes

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