反应详情

A mixture of methyl 4-bromo-2-(p-chlorophenyl)-1-(ethoxymethyl)-5-(trifluoromethyl)pyrrole-3-carboxylate (13.1 g) and potassium hydroxide (3.12 g, 85%, 48 mmol) is stirred at room temperature for 20 hours, stirred at reflux for 2 hours, diluted with water, washed with diethyl ether, acidified to pH 4 with 1N hydrochloric acid and filtered to obtain a solid. The solid is washed with water and petroleum ether and dried to give the title product as a white solid (6.45 g) which is identified by 1H NMR spectral analysis.

1. stirringstirred
2. temperatureat reflux for 2 hours
3. washwashed with diethyl ether
4. filtrationfiltered
5. customto obtain a solid
6. washThe solid is washed with water and petroleum ether
7. customdried