Pyridinium chloride → HCID 15237998, compound

HRID 274752Notes

Reaction equation

HRID 274752 reaction equation
C[O:2][C:3]([CH2:5][CH:6]1[CH2:15][CH2:14][C:13]2[C:8](=[CH:9][CH:10]=[CH:11][C:12]=2[O:16]C)[CH2:7]1)=[O:4].Cl.N1C=CC=CC=1>O>[C:3]([CH2:5][CH:6]1[CH2:15][CH2:14][C:13]2[C:8](=[CH:9][CH:10]=[CH:11][C:12]=2[OH:16])[CH2:7]1)([OH:4])=[O:2]

Participants

4

Reactant 2

HCID 10176127Pyridinium chlorideHCID 15237997HCID 15237997, compound

Product 1

HCID 15237998HCID 15237998, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
190 °C

Procedure

A mixture of 2-methoxycarbonylmethyl-5-methoxy-1,2,3,4-tetrahydronaphthalene (4.0 g) and pyridine hydrochloride (40 g) was stirred for 2 h at 190° C. The mixture was cooled to room temperature, dissolved into water. The mixture was extracted with ethyl acetate. The extract was washed with a saturated aqueous solution of sodium chloride, dried over anhydrous magnesium sulfate, and evaporated to give the title compound having the following physical data. The obtained residue was used for the next step without purification.

Workup

  1. temperatureThe mixture was cooled to room temperature
  2. extractionThe mixture was extracted with ethyl acetate
  3. washThe extract was washed with a saturated aqueous solution of sodium chloride
  4. dry with materialdried over anhydrous magnesium sulfate
  5. customevaporated

Sources & evidence

ORD record
ord-87af3c095a864f2092bd94d7e06a3eff
Source dataset
uspto-grants-1995_02
Patent number
US05389666

Reaction notes

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