Ammonia → N-(3,4,4-trifluoro-3-butenyl)ethanediamide

HRID 274786Notes

Reaction equation

HRID 274786 reaction equation
O=[C:2]([NH:9][C:10](=[O:15])[C:11](OC)=[O:12])[CH2:3][C:4]([F:8])=[C:5]([F:7])[F:6].[NH3:16]>CO>[F:8][C:4](=[C:5]([F:7])[F:6])[CH2:3][CH2:2][NH:9][C:10](=[O:15])[C:11]([NH2:16])=[O:12]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 86748464Oxo[(3,4,4-trifluoro-3-butenyl)amino]oxoacetic acid, methyl ester

Product 1

HCID 15239196N-(3,4,4-trifluoro-3-butenyl)ethanediamideYield 68%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of Compound 142 (5.0 g, 0.0237 mole) in methanol (50 mL) is saturated with dry gaseous ammonia at room temperature. The precipitate is filtered, washed with methanol and dried to give 3.16 g of the title compound as a white solid, a 68% yield. m.p. 190°-220° C.

Workup

  1. filtrationThe precipitate is filtered
  2. washwashed with methanol
  3. customdried

Sources & evidence

ORD record
ord-e185fa4a942f4db5be9998f8001bc23e
Source dataset
uspto-grants-1995_02
Patent number
US05389680

Reaction notes

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