Dipropylamine → 2-Di-n-propylamino-8-fluoro-1,2,3,4-tetrahydronaphthalene

Participants

Reaction Steps

8-Fluoro-2-tetralone (2.60 gm, 15.8 mMol) was reacted with dipropylamine (3.3 mL, 33 mMol) and sodium borohydride (1.5 gm) as described in Example 1 to give the title compound as a colorless oil (1.3 gm, 33%). The hydrochloride salt was formed and crystallization (ethanol/diethyl ether) gave colorless crystals (m.p.=164° C.).

Provenance & Evidence