HuagongsheHuagongshe Chemistry Print Report · For research reference only
Propylamine → 8-chloro-2-(N-n-propylamino)tetralin
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Propylamine | HCID 7852 | — |
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | 8-Chloro-1,2,3,4-tetrahydronaphthalen-2-one | HCID 4623269 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 8-chloro-2-(N-n-propylamino)tetralin | HCID 14969229 | — |
Reaction Steps
8-Chloro-2-tetralone (500 mg, 2.78 mMol) in toluene (25 mL) was reacted with propylamine (1.14 mL, 13.9 mMol) and sodium borohydride (500 rag) as described in Example2 to give after purification by flash chromatography (5% methanol in dichloromethane+tr. NH4OH) the title compound as a dark oil (340 mg, 55%). The hydrochloride was formed, and recrystallization (ethanol/diethyl ether) gave a colorless, crystalline solid (m.p.=213°-215° C.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05389687 |
| Source dataset | uspto-grants-1995_02 |
| ORD ID | ord-9d681bdd390848d68b15aa5fbf35ee22 |
| Source note | uspto-grants-1995_02 |