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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 274840Generated: October 30, 2026

Phosphorus tribromide → 1-(Bromomethyl)-2,5-dichloro-3-methoxybenzene

https://huagongshe.com/reaction/274840

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPhosphorus tribromideHCID 24614—
Reactant2,5-Dichloro-3-methoxybenzyl alcoholHCID 21478119—
SolventTolueneHCID 1140—
Product1-(Bromomethyl)-2,5-dichloro-3-methoxybenzeneHCID 2147810586.6%

Reaction Steps

By the method of Example 1, Step B, 13.95 grams (0.0674 mole) of 2,5-dichloro-3-methoxyphenylmethanol and 7.295 grams (0.270 mole) of phosphorus tribromide were reacted in toluene, yielding 15.76 grams of 2,5-dichloro-3-methoxyphenylmethyl bromide as an oil. The NMR spectrum was consistent with the proposed structure.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05391541
Source datasetuspto-grants-1995_02
ORD IDord-942650580d8246278ed783fcaa4a8104
Source noteuspto-grants-1995_02