HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Cyanide → 2,5-Dichloro-3-methoxyphenylacetonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Cyanide | HCID 8929 | — |
| Reactant | 1-(Bromomethyl)-2,5-dichloro-3-methoxybenzene | HCID 21478105 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2,5-Dichloro-3-methoxyphenylacetonitrile | HCID 54352190 | 97.4% |
Reaction Steps
By the method of Example 1, Step C, 15.40 grams (0.057 mole) of 2,5-dichloro-3-methoxyphenylmethyl bromide and 3.63 grams (0.074 mole ) of sodium cyanide were reacted in 70 mL of water and 65 mL of methanol, yielding 12.0 g of 2,5-dichloro-3-methoxyphenylacetonitrile as an oil that solidified on standing, m.p. 53°-57° C. The NMR and IR spectra were consistent with the proposed structure.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05391541 |
| Source dataset | uspto-grants-1995_02 |
| ORD ID | ord-17cb2a5faee44c58b3165e817791a110 |
| Source note | uspto-grants-1995_02 |