HuagongsheHuagongshe Chemistry Print Report · For research reference only
Iodine → 3-(2,3-Dichloro-5-iodophenylmethyl)-1-methyl-6-trifluoromethyluracil
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Iodine | HCID 807 | — |
| Reactant | Tert-Butyl nitrite | HCID 10906 | — |
| Reactant | 3-(5-Amino-2,3-dichlorophenylmethyl)-1-methyl-6-trifluoromethyluracil | HCID 21478122 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 3-(2,3-Dichloro-5-iodophenylmethyl)-1-methyl-6-trifluoromethyluracil | HCID 21478126 | 110.3% |
Reaction Steps
By the method of Example 2, Step B, 2.67 grams (0.00725 mole) of 3-(5-amino-2,3-dichlorophenylmethyl)-1-methyl-6-trifluoromethyluracil, 1.84 grams (0.00725 mole) of iodine, and 1.12 grams (0.0109 mole) of tertiarybutyl nitrite were reacted in 10 mL of dimethyl sulfoxide, yielding 3.83 grams of 3-(2,3-dichloro-5-iodophenylmethyl)-1-methyl-6-trifluoromethyluracil as a light brown solid, m.p. 142°-144° C. The NMR and IR spectra were consistent with the proposed structure.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05391541 |
| Source dataset | uspto-grants-1995_02 |
| ORD ID | ord-469edeee44ed4d70bb43d38f48e1ad12 |
| Source note | uspto-grants-1995_02 |