反应详情

9-Chloro-7-dodecyl-1,2,3,4-tetrahydroacridine (2.85 g) was heated at 150° in 60 mL of phenol containing 2.46 g of benzylamine. After 3 hours the reaction mixture was distributed between Et2O and 10% NaOH aqueous solution. The organic phase was washed once more with 10% NaOH, once with H2O, and then treated with 5% HCl. The insoluble hydrochloride was filtered off and recrystallized from isopropanol to give 2.15 g of analytically pure product, mp 194°-195°.

1. washThe organic phase was washed once more with 10% NaOH, once with H2O
2. additiontreated with 5% HCl
3. filtrationThe insoluble hydrochloride was filtered off
4. customrecrystallized from isopropanol
5. customto give 2.15 g of analytically pure product, mp 194°-195°