p-Toluenesulfonic acid → HCID 178440675, compound

Participants

Reaction Steps

A solution prepared from 25.0 g of 4-t-butylaniline-29.0 g of 2-ethoxycarbonylcyclohexanone, 100 ml of benzene and 0.20 g of p-toluenesulfonic acid was refluxed for 6 hours. At the end of this time no more water was collected from the reaction (Dean-Stark trap), so the benzene was evaporated and the residue was dissolved in 80 ml of diphenyl ether. This mixture was refluxed for 1 hour and then allowed to cool to room temperature overnight. The product which had precipitated from this solution was filtered off and washed well with diethyl ether to give 11.52 g of analytically pure product, m.p. 320°-322°.

Provenance & Evidence