反应详情

9-Chloro-7-decyl-1,2,3,4-tetrahydroacridine hydrochloride (5.0 g) was dissolved in 50 ml of phenol and heated at 150° C. with 3.50 g of benzylamine. After 2 hours at this temperature the reaction mixture was poured into 10% NaOH and extracted with Et2O. The organic phase was separated, washed with water and treated with 5% HCl. The insoluble hydrochloride was filtered off and recrystallized from MeOH/Et2O to give 2.59 g of product, m.p. 215° C.

1. extractionextracted with Et2O
2. customThe organic phase was separated
3. washwashed with water
4. additiontreated with 5% HCl
5. filtrationThe insoluble hydrochloride was filtered off
6. customrecrystallized from MeOH/Et2O