反应详情

A 4.0 g sample of 9-Chloro-7-dodecyl-1,2,3,4-tetrahydroacridine was heated at 150° C. as NH3 was bubbled into the solution. After 2 hours the reaction mixture was distributed between 10% NaOH and 2-butanone and then the organic phase was dried and concentrated. The residue was dissolved in Et2O and treated with 5% HCl. The insoluble hydrochloride was filtered off and recrystallized from MeOH/Et2O to give 2.32 g of analytically pure product, m.p. 257° d.

1. customwas bubbled into the solution
2. customthe organic phase was dried
3. concentrationconcentrated
4. dissolutionThe residue was dissolved in Et2O
5. additiontreated with 5% HCl
6. filtrationThe insoluble hydrochloride was filtered off
7. customrecrystallized from MeOH/Et2O
8. customto give 2.32 g of analytically pure product, m.p. 257°