反应详情

9.2 g (27.5 mmol) of methyl 3-(4,6-dimethoxypyrimidin-2-yl)oxy-6-dimethylaminopicolinate was dissolved in 30 ml of methanol, and 1.55 g (27.5 mmol) of 10% potassium hydroxide was added thereto. Furthermore, 20 ml of water was added thereto, and the resultant mixture was stirred at room temperature. The reaction liquor was concentrated under reduced pressure, and acetone was added thereto to precipitate a crystal. The crystal thus obtained was separated by filtration and was washed with hexane to obtain an aimed compound.

1. concentrationThe reaction liquor was concentrated under reduced pressure, and acetone
2. additionwas added
3. customto precipitate a crystal
4. customThe crystal thus obtained
5. customwas separated by filtration
6. washwas washed with hexane