Ethyl Acetate → HCID 20089208, compound

Participants

Reaction Steps

To a suspention of 4 mg (0.17 mmol) of sodium hydride in 1.0 mL of DMF was added 75 mg (0.17 mmol) of (3H)-benzimidazolone and the reaction mixture was stirred for 20 minutes. 75 mg (0.17 mmol) of 4-(1-carbomethoxy-1-(3-methylphenyl)methoxy)-3,5-dipropylbenzylbromide in 1.0 mL of DMF was added and the reaction mixture was stirred at room is temperature overnight. The reaction mixture was poured into ethyl acetate and washed with water and then brine. The organic layer was dried over sodium sulfate, decanted and concentrated. Purification by flash chromatography (silica gel, hexane/ethyl acetate 2:1) provided 41 mg of a dialkylated compound and 16 mg (0.03 mmol) of the title compound.

Provenance & Evidence