反应详情

N-Bromosuccinimide (3.95 g, 22.2 mmol) and AlBN (0.098 g, 0.06 mMol) were added to a solution of methyl (3,4-methylenedioxyphenyl)acetate (3.9 g, 21.2 mmol) in carbon tetrachloride and the mixture was refluxed for 2.5 h. The reaction was cooled and filtered. The flitrate was concentrated in vacuo and the residue obtained was purified by flash chromatography on silica-gel using 10% ethyl acetate-hexane. Yield 2.6 g (oil).

1. temperaturethe mixture was refluxed for 2.5 h
2. temperatureThe reaction was cooled
3. filtrationfiltered
4. concentrationThe flitrate was concentrated in vacuo
5. customthe residue obtained
6. customwas purified by flash chromatography on silica-gel