Hydrochloric Acid → HCID 15231784, compound

Participants

Reaction Steps

A round bottom flask was charged with 0.031 g (0.06 mmol) of the product of step C, 0.5 mL of ethanol and the flask and its contents were placed in a sonicator bath. Methylene chloride (0.2 mL) was then added in order to completely dissolve the starting material. Next, 23 μL of a 5.0 N solution of sodium hydroxide were added and the reaction was stirred at room temperature overnight. The reaction mixture was then adjusted to pH=5 with dropwise addition of 6 N hydrochloric acid, and then concentrated in vacuo. The residue was redissolved in methanol, filtered, and evaporated. The mixture was then purified on a silica gel flash chromatography column eluted with CHCl3 -MeOH-NH4OH (80: 15:1). Evaporation of the purified fractions and drying in vacuo afforded 0.012 g (48%) of the title compound.

Provenance & Evidence