Sodium Hydroxide → HCID 15231787, compound

Participants

Reaction Steps

The product from Step D was taken up in 10 mL of methanol and 4 mL 5N NaOH(aq) was added with stirring at room temperature. The reaction was stirred for 3 hours and the volatiles removed in vacuo. The resultant slurry was diluted with 50 mL H2O and acidified with 1N HCl (aq) and extracted with 3×20 mL ethyl acetate. The combined organics were concentrated in vacuo. Trituration of the resultant oil with ethyl ether gave 64 mg (82%-2 steps) of the title compound as a white solid.

Provenance & Evidence