Formic Acid → HCID 178507840, compound

HRID 274965Notes

Reaction equation

HRID 274965 reaction equation
[NH2:1][C:2]1[C:7]([Cl:8])=[CH:6][C:5]([S:9]([NH:12][CH:13]([CH2:26][C:27]2[CH:32]=[CH:31][C:30]([NH2:33])=[C:29]([N+:34]([O-])=O)[CH:28]=2)[C:14]([N:16]2[CH2:22][CH2:21][C:20]3[CH:23]=[CH:24][S:25][C:19]=3[CH2:18][CH2:17]2)=[O:15])(=[O:11])=[O:10])=[CH:4][C:3]=1[Cl:37].[CH:38](O)=O>[Pd]>[NH2:1][C:2]1[C:7]([Cl:8])=[CH:6][C:5]([S:9]([NH:12][CH:13]([CH2:26][C:27]2[CH:32]=[CH:31][C:30]3[NH:33][CH:38]=[N:34][C:29]=3[CH:28]=2)[C:14]([N:16]2[CH2:22][CH2:21][C:20]3[CH:23]=[CH:24][S:25][C:19]=3[CH2:18][CH2:17]2)=[O:15])(=[O:11])=[O:10])=[CH:4][C:3]=1[Cl:37]

Participants

4

Reactant 2

HCID 284Formic AcidHCID 20089090HCID 20089090, compound

Product 1

HCID 178507840HCID 178507840, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

Prepared from 4-amino-N-[1-((4-amino-3-nitro-phenyl)methyl)-2-(5,6,7,8-tetrahydro-4H-thieno[2,3-d]azepin-6-yl)-2-oxo-ethyl]-3,5-dichloro-benzenesulphonamide and cyclising with formic acid in the presence of palladium/charcoal analogously to Example 1.

Sources & evidence

ORD record
ord-014b0c440fa74c65bccb7f04560fea1f
Source dataset
uspto-grants-1995_02
Patent number
US05391556

Reaction notes

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