Formic Acid → HCID 178428648, compound

HRID 274966Notes

Reaction equation

HRID 274966 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH:9]([NH:19][S:20]([C:23]2[CH:28]=[C:27]([C:29]([CH3:32])([CH3:31])[CH3:30])[C:26]([OH:33])=[C:25]([C:34]([CH3:37])([CH3:36])[CH3:35])[CH:24]=2)(=[O:22])=[O:21])[C:10]([N:12]2[CH2:17][CH2:16][CH:15]([CH3:18])[CH2:14][CH2:13]2)=[O:11])=[CH:4][C:3]=1[N+:38]([O-])=O.[CH:41](O)=O>[Pd]>[NH:1]1[C:2]2[CH:7]=[CH:6][C:5]([CH2:8][CH:9]([NH:19][S:20]([C:23]3[CH:28]=[C:27]([C:29]([CH3:32])([CH3:31])[CH3:30])[C:26]([OH:33])=[C:25]([C:34]([CH3:37])([CH3:36])[CH3:35])[CH:24]=3)(=[O:22])=[O:21])[C:10]([N:12]3[CH2:17][CH2:16][CH:15]([CH3:18])[CH2:14][CH2:13]3)=[O:11])=[CH:4][C:3]=2[N:38]=[CH:41]1

Participants

4

Reactant 2

HCID 284Formic AcidHCID 20089119HCID 20089119, compound

Product 1

HCID 178428648HCID 178428648, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

Prepared from N-[1-((4-amino-3-nitro-phenyl)-methyl)-2-(4-methyl-piperidin-1-yl)-2-oxo-ethyl]-3,5-di-tert.butyl-4-hydroxy-benzenesulphonamide and cyclising with formic acid in the presence of palladium/charcoal analogously to Example 1.

Sources & evidence

ORD record
ord-0963946d6794434cac84f539da816d76
Source dataset
uspto-grants-1995_02
Patent number
US05391556

Reaction notes

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