Formic Acid → HCID 178439394, compound

HRID 274968Notes

Reaction equation

HRID 274968 reaction equation
[NH2:1][C:2]1[C:7]([Cl:8])=[CH:6][C:5]([S:9]([NH:12][CH:13]([CH2:25][C:26]2[CH:31]=[CH:30][C:29]([NH2:32])=[C:28]([N+:33]([O-])=O)[CH:27]=2)[C:14]([N:16]2[CH2:21][CH2:20][CH:19]([CH2:22][CH2:23][CH3:24])[CH2:18][CH2:17]2)=[O:15])(=[O:11])=[O:10])=[CH:4][C:3]=1[Cl:36].[CH:37](O)=O>[Pd]>[NH2:1][C:2]1[C:7]([Cl:8])=[CH:6][C:5]([S:9]([NH:12][CH:13]([CH2:25][C:26]2[CH:31]=[CH:30][C:29]3[NH:32][CH:37]=[N:33][C:28]=3[CH:27]=2)[C:14]([N:16]2[CH2:21][CH2:20][CH:19]([CH2:22][CH2:23][CH3:24])[CH2:18][CH2:17]2)=[O:15])(=[O:11])=[O:10])=[CH:4][C:3]=1[Cl:36]

Participants

4

Reactant 2

HCID 284Formic AcidHCID 20089048HCID 20089048, compound

Product 1

HCID 178439394HCID 178439394, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

Prepared from 4-amino-N-[1-((4-amino-3-nitro-phenyl)methyl)-2-(4-propyl-piperidin-1-yl)-2-oxo-ethyl]-3,5-dichloro-benzenesulphonamide and cyclising with formic acid in the presence of palladium/charcoal analogously to Example 1.

Sources & evidence

ORD record
ord-e3e4c24e276e476a9dd00e20dc77114a
Source dataset
uspto-grants-1995_02
Patent number
US05391556

Reaction notes

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