Formic Acid → HCID 178428641, compound

HRID 274972Notes

Reaction equation

HRID 274972 reaction equation
[CH:1]1([C:7]2[CH:12]=[CH:11][C:10]([S:13]([NH:16][CH:17]([CH2:27][C:28]3[CH:33]=[CH:32][C:31]([NH2:34])=[C:30]([N+:35]([O-])=O)[CH:29]=3)[C:18]([N:20]3[CH2:25][CH2:24][CH:23]([CH3:26])[CH2:22][CH2:21]3)=[O:19])(=[O:15])=[O:14])=[CH:9][CH:8]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH:38](O)=O>[Pd]>[CH:1]1([C:7]2[CH:12]=[CH:11][C:10]([S:13]([NH:16][CH:17]([CH2:27][C:28]3[CH:33]=[CH:32][C:31]4[NH:34][CH:38]=[N:35][C:30]=4[CH:29]=3)[C:18]([N:20]3[CH2:25][CH2:24][CH:23]([CH3:26])[CH2:22][CH2:21]3)=[O:19])(=[O:15])=[O:14])=[CH:9][CH:8]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 284Formic AcidHCID 20089100HCID 20089100, compound

Product 1

HCID 178428641HCID 178428641, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

Prepared from 4-cyclohexyl-N-[1-((4-amino-3-nitrophenyl)-methyl)-2-(4-methyl-piperidin-1-yl)-2-oxoethyl]-benzenesulphonamide and cyclising with formic acid in the presence of palladium/charcoal analogously to Example 1.

Sources & evidence

ORD record
ord-ccafe4b303494567943b3f7c1d233d12
Source dataset
uspto-grants-1995_02
Patent number
US05391556

Reaction notes

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