HCID 178430074, compound → HCID 178428639, compound

HRID 274979Notes

Reaction equation

HRID 274979 reaction equation
[NH:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH2:10][CH:11]([NH:21][S:22]([C:25]3[CH:26]=[CH:27][CH:28]=[C:29]4[C:34]=3[N:33]=[CH:32][C:31]([CH3:35])=[CH:30]4)(=[O:24])=[O:23])[C:12]([N:14]3[CH2:19][CH2:18][CH:17]([CH3:20])[CH2:16][CH2:15]3)=[O:13])=[CH:9][C:4]=2[N:3]=[CH:2]1>C(O)(=O)C.[Pd]>[NH:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH2:10][CH:11]([NH:21][S:22]([C:25]3[CH:26]=[CH:27][CH:28]=[C:29]4[C:34]=3[NH:33][CH2:32][CH:31]([CH3:35])[CH2:30]4)(=[O:24])=[O:23])[C:12]([N:14]3[CH2:19][CH2:18][CH:17]([CH3:20])[CH2:16][CH2:15]3)=[O:13])=[CH:9][C:4]=2[N:3]=[CH:2]1

Participants

4

Reactant 1

HCID 178430074HCID 178430074, compound

Product 1

HCID 178428639HCID 178428639, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 176Acetic AcidSolvent

Procedure

Prepared by catalytic hydrogenation of N-[1-(1H-benzimidazol-5-yl-methyl)-2-(4-methyl-piperidin-1-yl)-2-oxoethyl]-3-methyl-quinoline-8-sulphonamide in the presence of palladium/charcoal in 50% acetic acid and under a hydrogen pressure of 3 bar analogously to Example 35.

Sources & evidence

ORD record
ord-f190c9ec8c4f425f8c3495cfabf6af5d
Source dataset
uspto-grants-1995_02
Patent number
US05391556

Reaction notes

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