Acetyl chloride → HCID 54401905, compound

Participants

Reaction Steps

To a solution of 2 g (0.0142 mol) of 1-methyl-1,2,5,6-tetrahydropyridin-3-carboxaldehyde-oxime [Chem. Ber. 40, 4712, (1907) in 20 CM3 of anhydrous THF, 1.44 g (0.0142 mol) of triethylamine and 1.12 g (0.0142 mol) of acetyl chloride are added, with agitation for 1 hour at ambient temperature. The reactional mixture is treated with water, then with an aqueous solution of sodium bicarbonate; the organic phase is separated, dried and the solvent is evaporated. The residue is distilled at 0.05 mm of Hg, collecting the fraction with b.p. 170°-175°. Yield 2.1 g (81%).

Provenance & Evidence