HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methylamine → N-cyano-N'-methyl-N"-[2-(2-pyrimidylmethylthio)ethyl]guanidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | 2-(Chloromethyl)pyrimidine | HCID 12877371 | — |
| Reactant | 2-[(2-Aminoethyl)thiomethyl]pyrimidine | HCID 20242485 | — |
| Reactant | 2-(1-Sulfanylethyl)isoindole-1,3-dione | HCID 21404713 | — |
| Product | N-cyano-N'-methyl-N"-[2-(2-pyrimidylmethylthio)ethyl]guanidine | HCID 178484995 | — |
Reaction Steps
Reacting 2-chloromethylpyrimidine with phthalimidoethanethiol by the procedure of Example 1(i)(b) and then reacting the resulting 2-[(2-aminoethyl)thiomethyl]-pyrimidine with dimethyl-N-cyanoimidodithiocarbonate and methylamine by the procedure of Example 3(d) gives N-cyano-N'-methyl-N"-[2-(2pyrimidylmethylthio)ethyl]-guanidine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04221802 |
| Source dataset | uspto-grants-1980_09 |
| ORD ID | ord-7de3e90871484be8a339f72d74bb3a08 |
| Source note | uspto-grants-1980_09 |