HuagongsheHuagongshe Chemistry Print Report · For research reference only
Citric Acid → 2-(Oxolan-3-yl)ethan-1-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Citric Acid | HCID 311 | — |
| Reactant | Ethanol | HCID 702 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Solvent | 1-Butanol | HCID 263 | — |
| Product | (Oxan-4-yl)methanol | HCID 2773573 | 1.5% |
| Product | 2-(Oxolan-3-yl)ethan-1-ol | HCID 11126225 | 52% |
Reaction Steps
400 g of citric acid were dissolved in 1000 ml of n-butanol and hydrogenated at 250° C. and 200 bar together with 60 g of catalyst A (4-mm pellets) until the take-up of hydrogen had ceased. The reaction product was freed from n-butanol and ethanol and distilled under reduced pressure, giving 99 g (52%) of 3-(2'-hydroxyethyl)tetrahydrofuran and 2.9 g (1.5%) of 4-hydroxymethyltetrahydropyran.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05391771 |
| Source dataset | uspto-grants-1995_02 |
| ORD ID | ord-8855e12654a647c08c93ecb4637923f7 |
| Source note | uspto-grants-1995_02 |