HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethyl Citrate → 2-(Oxolan-3-yl)ethan-1-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethyl Citrate | HCID 6506 | — |
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | (Oxan-4-yl)methanol | HCID 2773573 | 3.6% |
| Product | 2-(Oxolan-3-yl)ethan-1-ol | HCID 11126225 | 49% |
Reaction Steps
400 ml of triethyl citrate were hydrogenated at 225° C. and 200 bar together with 1100 ml of tetrahydrofuran and 60 g of catalyst H (3-mm tablets) until the take-up of hydrogen had ceased. The reaction product was freed from tetrahydrofuran and ethanol and distilled under reduced pressure, giving 93.6 g (49%) of 3-(2'-hydroxyethyl)tetrahydrofuran and 6.8 g (3.6%) of 4-hydroxymethyltetrahydropyran.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05391771 |
| Source dataset | uspto-grants-1995_02 |
| ORD ID | ord-e0c800179a6a41f3800b0b39c6564e34 |
| Source note | uspto-grants-1995_02 |