Potassium Hydroxide → HCID 54147323, compound

Participants

Reaction Steps

To a solution of 17β-methoxycarbonylmethylaminocarbonyloxy-3-methoxymethyloxy-1,3,5-estratriene (0.77 g) in methanol (40 ml) was added 2 N aqueous potassium hydroxide (6 ml), and the resultant mixture was stirred at room temperature for 2 hours. The reaction mixture was mixed with ion exchange resin (DOWEX, 5W-X8), neutralized, and filtered to remove the ion exchange resin. The filtrate was concentrated in vacuo to give 17β-carboxymethylaminocarbonyloxy-3-methoxymethyloxy-1,3,5-estratriene (0.65 g, Yield: 88%) as an amorphous solid.

Provenance & Evidence