2-[(2-Aminoethyl)thiomethyl]pyrazine → HCID 178512220, compound

HRID 27509Notes

Reaction equation

HRID 27509 reaction equation
[NH2:1][CH2:2][CH2:3][S:4][CH2:5][C:6]1[CH:11]=[N:10][CH:9]=[CH:8][N:7]=1.CS[C:14](=[NH:19])[NH:15][N+:16]([O-:18])=[O:17]>>[N+:16]([NH:15][C:14]([NH:1][CH2:2][CH2:3][S:4][CH2:5][C:6]1[CH:11]=[N:10][CH:9]=[CH:8][N:7]=1)=[NH:19])([O-:18])=[O:17]

Participants

3

Reactant 2

HCID 129234132-[(2-Aminoethyl)thiomethyl]pyrazineHCID 135927615N-Nitro-S-methylisothiourea

Product 1

HCID 178512220HCID 178512220, compound

Procedure

Reaction of 2-[(2-aminoethyl)thiomethyl]pyrazine with S-methyl-N-nitroisothiourea by the procedure of Example 2(ii) gives N-nitro-N'-[2-(2-pyrazinylmethylthio)ethyl]guanidine. Similarly by the procedure of Example 2 (iii), there is prepared N-methyl-N'-nitro-N"-[2-(2-pyrazinylmethylthio)ethyl]guanidine.

Sources & evidence

ORD record
ord-29edbbdb9ae548f9aa805056bad10ae3
Source dataset
uspto-grants-1980_09
Patent number
US04221802

Reaction notes

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