3-Mercaptopropionic Acid → Thiodipropionic Acid

HRID 275105Notes

Reaction equation

HRID 275105 reaction equation
SCCC(O)=O.[S:7]([CH2:13][CH2:14][C:15]([O-:17])=[O:16])[CH2:8][CH2:9][C:10]([O-:12])=[O:11]>>[S:7]([CH2:13][CH2:14][C:15]([OH:17])=[O:16])[CH2:8][CH2:9][C:10]([OH:12])=[O:11]

Participants

3

Reactant 2

HCID 65143-Mercaptopropionic AcidHCID 15496243,3'-Thiodipropanoate

Product 1

HCID 8096Thiodipropionic Acid

Procedure

U.S. Pat. No. 5,256,818 to Tomioka discloses a method for making β-mercaptopropionic acid (HSCH2XH2COOH) by reacting alkaline thiodipropionate obtained from solid thiodipropionic acid, with alkaline sulfide. Specifically, sodium or potassium hydroxide is used to convert solid thiodipropionic acid to the corresponding thiodipropionate, which in turn is reacted with sodium sulfide at a temperature of 110° to 130° C. for one or several hours, preferably in the presence of residual alkaline hydroxide. The resulting solution is acidified with a strong acid to form the β-mercaptopropionic acid.

Sources & evidence

ORD record
ord-5967f98e58994061b69f4edd99da21dc
Source dataset
uspto-grants-1995_02
Patent number
US05391820

Reaction notes

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