反应详情

N-Bromosuccinimide (3.2 g.) and benzoyl peroxide (0.005 g.) were added to a solution of 3-methoxy-4-methylbenzonitrile (2.65 g.) in dry carbon tetrachloride (90 ml.). The mixture was heated to reflux for 15 minutes using a 250 watt tungsten lamp. The cooled reaction mixture was diluted with petrolum ether (b.p. 60°-80° C., 90 ml.), insoluble material removed by filtration, and the filtrate evaporated. The solid residue was recrystallized from a mixture of dichloromethane and petroleum ether to give 4-bromomethyl-3-methoxybenzonitrile (W) (2.64 g. , 65% ) as a white solid, m.p. 87°-91° C.

1. temperatureThe mixture was heated
2. temperatureto reflux for 15 minutes
3. customThe cooled reaction mixture
4. customremoved by filtration
5. customthe filtrate evaporated
6. customThe solid residue was recrystallized from a mixture of dichloromethane and petroleum ether