HCID 54523463, compound → HCID 54114202, compound

HRID 275245Notes

Reaction equation

HRID 275245 reaction equation
[CH2:1]([C:6]1[CH:11]=[CH:10][C:9]([C:12]#[C:13][C:14]2[CH:15]=[N:16][C:17]([C:20]3[CH:37]=[CH:36][C:23]([C:24]([O:26][CH2:27][C@@H:28]([F:35])[CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH3:34])=[O:25])=[CH:22][CH:21]=3)=[N:18][CH:19]=2)=[CH:8][CH:7]=1)[CH2:2][CH2:3][CH2:4][CH3:5].[H][H]>[Pd]>[CH2:1]([C:6]1[CH:7]=[CH:8][C:9]([CH2:12][CH2:13][C:14]2[CH:15]=[N:16][C:17]([C:20]3[CH:21]=[CH:22][C:23]([C:24]([O:26][CH2:27][C@@H:28]([F:35])[CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH3:34])=[O:25])=[CH:36][CH:37]=3)=[N:18][CH:19]=2)=[CH:10][CH:11]=1)[CH2:2][CH2:3][CH2:4][CH3:5]

Participants

4

Reactant 2

HCID 54523463HCID 54523463, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 54114202HCID 54114202, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

Hydrogenation of the compound obtained in Example 4 using hydrogen under atmospheric pressure at room temperature and using palladium/charcoal as catalyst gives (S)-2-fluorooctyl 4-{5-[2-(4-pentylphenyl)ethyl]-pyrimidin-2-yl}benzoate.

Workup

  1. customat room temperature

Sources & evidence

ORD record
ord-ebc9e48692ca49e38abe686f0d097273
Source dataset
uspto-grants-1995_02
Patent number
US05393459

Reaction notes

Loading…