HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Trifluoromethyl)phenylhydrazine → 2-(3-Trifluoromethylbenzoyl)nicotinic acid (4-trifluoromethylphenyl)hydrazone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Trifluoromethyl)phenylhydrazine | HCID 136200 | — |
| Reactant | 2-(3-Trifluoromethylbenzoyl)nicotinic acid | HCID 20078895 | — |
| Catalyst | p-Toluenesulfonic acid | HCID 6101 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-(3-Trifluoromethylbenzoyl)nicotinic acid (4-trifluoromethylphenyl)hydrazone | HCID 178519560 | 80.7% |
Reaction Steps
2-(3-Trifluoromethylbenzoyl)nicotinic acid (0.5 g), 4-trifluoromethylphenylhydrazine (0.3 g) and para-toluene sulphonic acid (0.001 g) were stirred in methanol at room temperature for 22 hours. Solvent was evaporated. The residue was triturated in cold toluene then dried to yield the title compound as a beige solid (0.62 g), m.p. 127°-129° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05393730 |
| Source dataset | uspto-grants-1995_02 |
| ORD ID | ord-0f21748979904a6cb9e4027cefd1fe85 |
| Source note | uspto-grants-1995_02 |